Sassuolo vs Lazio Predictions

Sassuolo vs Lazio predictions in our match preview for this Serie A clash. Sassuolo, still pointless, host Lazio at Mapei Stadium in Serie A’s third round on Sunday, hoping to clinch their first win of the campaign. Read on for all our free predictions and betting tips.

Serie A | Sep 14 2025 at 5:00 pm UK at Mapei Stadium

Sassuolo vs Lazio Predictions

Can Sassuolo Stop the Slide or Will Lazio’s Firepower Prove Too Much?

• Sassuolo leaking goals under pressure
  • The Neroverdi conceded five times across their first two Serie A matches, with defensive lapses costing them dearly in both fixtures.
• Lazio’s scoring depth shines through
  • Four different players found the net in their 4-0 victory over Verona, underlining the attacking variety Sarri now has at his disposal.
• Sassuolo’s attack keeps them alive
  • Despite defeats, Berardi and Pinamonti both scored last time out, proving that Sassuolo’s frontline is still capable of making defences uncomfortable.

Best Bet for Sassuolo vs Lazio

The Mapei Stadium is preparing for another tense Sunday evening as Sassuolo, still without a single point on their Serie A return, try to stop the rot against a Lazio side full of confidence. Fabio Grosso’s men have endured a rough reintroduction to the top flight, losing to Napoli and then heartbreakingly at Cremonese despite a spirited comeback. To rub salt into the wound, they are now up against a team who have beaten them on their last two visits to Emilia-Romagna without even conceding.

For Lazio, the mood is far brighter. Maurizio Sarri watched his side crumble at Como on the opening day, but their emphatic 4-0 demolition of Verona before the break showed what they are capable of. With four different goalscorers in that win, the Biancocelesti reminded everyone that they have both depth and flair in the attacking third. The capital club are dreaming of pushing up the table again, and few will back against them making it two wins on the bounce here. Sassuolo, however, have pride to defend, and a noisy home crowd who will not accept another collapse. Expect emotions to run high – and perhaps a few nerves jangling too.

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Best Bet for This Match

At BettingTips4You we believe in cutting through the noise. Rather than overwhelm you with multiple possibilities, we pick a single Best Bet for each clash. It’s about accountability and making life simpler for our readers. For Sassuolo versus Lazio, the bet we are going with is Lazio to win and both teams to score.

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Sassuolo are pointless but not toothless. Against Cremonese, they showed resilience by coming from two goals down, with Andrea Pinamonti and Domenico Berardi both hitting the net. They have the quality in attack to trouble anyone, and Josh Doig’s energy from the flanks continues to supply opportunities. The issue is obvious: their defence. Fabio Grosso’s back line conceded three last time out and looked vulnerable under pressure. Even Napoli, who barely got out of second gear, found two goals with relative ease.

Lazio, by contrast, carry momentum. Four goals against Verona, spread among Matteo Guendouzi, Mattia Zaccagni, Valentin Castellanos and Boulaye Dia, showed they are not reliant on one man. Castellanos, in particular, looked electric, providing two assists as well as a goal. With Manuel Lazzari the only confirmed absentee and others pushing through knocks, Sarri has options aplenty. The BettingTips4You Expert Rating suggests Lazio are among the sharpest attacking sides so far, and even on the road they are expected to create plenty.

Sassuolo will not simply roll over – they are desperate to get their first points, and Berardi in particular thrives in games where the odds are stacked against him. That said, their defensive cracks are too wide to ignore, and Lazio have the weapons to exploit them.

BettingTips4You.com expert Luca Semproni put it best:

“Sassuolo can score, but they cannot keep the back door shut. Lazio’s forwards will punish them, yet Berardi and Pinamonti can still make it interesting.”

Taking everything into account, Lazio’s superior quality should see them edge this. Sassuolo’s fight will produce a goal, but ultimately the visitors’ firepower looks decisive. A 3-1 away win feels the most likely outcome, with Sarri’s men taking control but not keeping things spotless at the back.

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