Napoli vs Pisa Predictions

Napoli vs Pisa Predictions for Monday’s Serie A fixture at the Stadio Diego Armando Maradona. Napoli, reigning Italian champions, host promoted Pisa at Stadio Maradona on Monday, seeking Serie A redemption after recent European disappointment. Read on for all our predictions and free betting tips for the game.

Serie A | Sep 22 2025 at 7:45 pm UK at Stadio Maradona

Napoli vs Pisa Predictions

Will Napoli Cruise or Can Pisa Spring a Surprise at the Maradona?

• Napoli’s perfect start: Three wins from three in Serie A, conceding just once, showing their balance between defensive solidity and attacking quality.
• Pisa’s goal drought: Their only “goal” in Serie A came via an Atalanta own goal, highlighting how blunt their attack has been so far.
• Fortress Maradona: Napoli have won six of their last seven home league matches, keeping four clean sheets during that impressive run.

Best Bet for Napoli vs Pisa

There’s a real sense of anticipation in Naples as the champions return to league business on Monday night. Fresh off a disappointing midweek defeat in Europe, Napoli will look to shake off that frustration as they welcome newcomers Pisa to the Maradona. The contrast could hardly be sharper: Conte’s men are unbeaten domestically and playing with a swagger, while Pisa are still searching for their first Serie A victory, having managed just a single point so far.

The visitors come here with little more than hope, yet football has a funny way of humbling even the most confident sides. Napoli fans will expect nothing less than a statement win, but Pisa will try to frustrate and perhaps nick something if the hosts don’t click. After all, nerves sometimes creep in when you’re such heavy favourites. Still, considering Napoli’s depth and the way they’ve started their title defence, anything other than three points for the Partenopei would raise serious questions.

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Best Bet for Napoli vs Pisa

At BettingTips4You we pride ourselves on precision, not clutter. Instead of throwing a dozen half-baked suggestions around, we select the single bet that genuinely stands out. For this clash, the tip that rises above the rest is Napoli to win without conceding.

Why? Because all the evidence points to this scenario. Napoli’s Serie A start has been flawless, three wins from three, with only one goal allowed in the process. Even when they fell short against Manchester City, it wasn’t their defensive structure that collapsed—it was a red card that tipped the scales. Back at home, with their full squad (minus a couple of absentees) available, this looks like the perfect setting to reassert dominance.

Pisa’s problem is brutally simple: they cannot score. Across their three league outings, the only “goal” in their favour was an Atalanta own goal. Against Roma and Udinese they looked toothless, managing only scraps of chances. Even their Coppa Italia tie against Cesena dragged into penalties after a 0-0. With the likes of Nzola still trying to settle and Moreo struggling for impact, Gilardino has an attack that doesn’t frighten anyone, least of all a Napoli defence marshalled by Di Lorenzo and Spinazzola.

Up front, Conte has options. De Bruyne will be desperate to make amends after his quiet night in Manchester, Lucca has extra motivation facing his old club, and Politano’s work rate guarantees constant pressure on Pisa’s back line. Even without Lukaku and Rrahmani, Napoli’s squad still looks several levels above their guests.

As BettingTips4You.com expert Luca Semproni put it:

“When champions face a side still searching for their first proper goal, the script almost writes itself. Napoli’s clean sheet is just as important as the victory.”

He’s right. This isn’t just about Napoli scoring two or three goals, it’s about shutting down Pisa entirely and showing the ruthlessness expected of a Scudetto holder. The Partenopei have been clinical at home, and with Pisa unlikely to muster much in the way of attacking threat, the odds of a comfortable win to nil are far too strong to ignore.

For the correct score, 3-0 feels the best fit. Napoli’s average across their opening Serie A matches has been around two goals a game, and against a Pisa side yet to test top-level defences properly, an extra strike looks likely. It should be one of those nights where the champions flex just enough muscle without needing to go into overdrive.

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