Manchester United vs Lyon Predictions

Manchester United vs Lyon predictions for this Europa League tie. Manchester United and Lyon meet at Old Trafford after a thrilling 2-2 first leg, with United’s strong home form and attacking depth making them slight favourites to edge this Europa League quarter-final tie. Read on for all our free predictions and betting tips.

Europa League | Apr 17, 2025 at 8pm UK at Old Trafford

Manchester United vs Lyon Predictions

Is the Theatre of Dreams Set for Another Epic Night or Another Meltdown?

• Chaos on the Cards: Both teams have found the net in five of Manchester United’s last six matches, with defensive errors consistently proving costly.
• Les Gones Don’t Fear the Road: Lyon have scored 17 goals in their last seven away games, conceding 11. They’ve only lost twice in that run, showing they travel well.
• Cherki Catching Fire: Rayan Cherki has netted in each of his last three matches and has contributed to 11 goals in this Europa League campaign alone. He’s United’s biggest headache right now.

Best Bet for Manchester United vs Lyon

Old Trafford awaits another charged European evening as Manchester United welcome Lyon for the second leg of their Europa League quarter-final. After the first encounter ended in a thrilling 2-2 draw over in France, all bets are off heading into Thursday night’s decisive clash. With Champions League qualification all but gone through the domestic route for both sides, the pressure has never felt more suffocating. It’s win or wave goodbye to the season.

Manchester United arrive in Manchester looking like a team on the verge of something—whether it’s redemption or total collapse remains to be seen. Their dismal 4-1 hammering at Newcastle last weekend only intensified scrutiny on Ruben Amorim and the error-prone Andre Onana. The Cameroonian keeper was notably absent from that match, presumably to ‘reset’ after his howlers in the first leg, but he’s likely to be thrown straight back into the fire.

Lyon, meanwhile, are buzzing. Since grabbing that dramatic stoppage-time equaliser courtesy of Rayan Cherki, they’ve marched on with confidence, dispatching Auxerre 3-1 at the weekend and closing the gap in Ligue 1’s top three. They’ve now gone twelve Europa League away games unbeaten—more than just a fluke, that’s a habit.

Both sides are flawed, fragile, and yet fully aware that this tie could define their seasons. Expect fireworks.

Best Bet for Manchester United vs Lyon: Both Teams to Score

Here at BettingTips4You, we don’t believe in flooding readers with twenty predictions and hoping one sticks. We cut through the noise and give you one prediction per game—the one with the best value, and the one we believe in most. For this showdown at Old Trafford, our Best Bet is Both Teams to Score.

Now, let’s be honest for a second. Picking a clean sheet on either side here feels more like blind hope than sound logic. Manchester United are shipping goals for fun lately—four against Newcastle, two against Lyon, and more defensive mix-ups than a Sunday league back four. They haven’t looked settled at the back all season, and even though Maguire might return alongside the youngster Yoro, it’s hardly a defensive pairing to strike fear into Lyon’s dynamic forward line.

And speaking of Lyon, they’re not exactly shy in front of goal themselves. Cherki’s current form is bordering on outrageous—three goals in his last three games, including that last-gasp equaliser in the first leg. Add to that the threat of Almada’s creativity and Mikautadze’s movement, and you’ve got a team that can—and probably will—punish any slip-up.

Even without Zirkzee, United should have enough attacking firepower to get themselves on the scoresheet. Garnacho ended his goal drought last weekend, Fernandes is always lurking for a moment of brilliance, and Hojlund will be desperate to seize his starting chance with Zirkzee sidelined.

Neither team can afford to sit back. The stakes are too high, the margins too fine. And with both sides showing serious defensive vulnerabilities but plenty of attacking flair, it just screams goals at both ends.

As BettingTips4You.com expert Tyler Morris puts it:
“If you’ve seen either of these teams defend lately, you’ll know why we’re backing goals. Neither side can keep a clean sheet with duct tape, let alone discipline.”

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Likely Correct Score: Manchester United 2-2 Lyon (United win on penalties)

Given how evenly matched these teams were in the first leg and how poor both have been defensively, a repeat scoreline is more than possible. United might create more in front of their own crowd, but Lyon’s threat on the counter—and their confidence—means they should find the net. A 2-2 draw again, with United just edging it on penalties, feels like the kind of chaos this tie deserves.

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