Inter Milan vs Sassuolo Predictions

Inter vs Sassuolo Predictions for this Serie A tussle at the Stadio Giuseppe Meazza. Inter Milan, buoyed by their Champions League return, host Sassuolo on Sunday, targeting a Serie A victory to regain momentum after recent domestic setbacks. Read on for all our predictions and free betting tips for the game.

Serie A | Sep 21 2025 at 7:45 pm UK at the Stadio Giuseppe Meazza

Inter Milan vs Sassuolo Predictions

Can Inter Avoid Another Slip or Will Sassuolo Spring a Surprise at San Siro?

• Inter struggling for consistency
  • Two defeats in three Serie A matches under Chivu show the Nerazzurri are still adjusting, despite their Champions League win over Ajax.
• Sassuolo’s attacking threat alive
  • Fadera’s goal against Lazio highlighted their depth in forward options, while Berardi has scored seven Serie A goals at San Siro across his career.
• Goals expected from both ends
  • Inter have conceded six goals in their last two league matches, while Sassuolo have scored in three of their last four games in all competitions.

Best Bet for Inter Milan vs Sassuolo

Inter Milan return to Serie A action this weekend with more than just points on the line. Fresh from a morale-boosting 2-0 victory over Ajax in the Champions League, Cristian Chivu’s side are back at San Siro, determined to repair the domestic damage caused by back-to-back league defeats. Their supporters know this squad still has the quality to challenge at the top, but patience will quickly run out if slip-ups keep happening against sides they are expected to beat.

Standing in their way are Sassuolo, who have already shown they can upset the bigger names. Fabio Grosso’s men arrive in Milan after a remarkable win over Lazio, secured by Alieu Fadera’s instant impact from the bench. Though inconsistent, Sassuolo carry attacking flair, and their history at San Siro suggests they rarely make life easy for Inter. Domenico Berardi, who has made a career out of tormenting the Nerazzurri, will no doubt relish the chance to add to his tally in this fixture.

With Inter’s focus split between chasing Juventus and Napoli in the league and balancing the demands of Europe, this match has the makings of a nervy affair. The home crowd will demand dominance, but Sassuolo are unlikely to simply roll over.

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Best Bet for this Match

Here at BettingTips4You, we keep things straightforward: one game, one prediction. That means no confusion, just the clearest insight into where the value lies. For Inter Milan against Sassuolo, our Best Bet is Both Teams to Score.

Inter may have looked composed in Amsterdam, but their Serie A outings tell a different story. They were hammered by Udinese at home and then dragged into a chaotic Derby d’Italia where their defence collapsed late on. Even with Manuel Akanji strengthening the back line, doubts remain, and Sassuolo’s front three of Berardi, Andrea Pinamonti and Armand Lauriente have the dynamism to expose those weaknesses. Add Fadera’s lively presence as an option, and the visitors have the tools to make their mark.

On the flip side, Inter’s attacking quality is undeniable. Marcus Thuram is in lethal form, bagging a brace in Europe, while Lautaro Martinez should return to the starting eleven after being rested midweek. With Hakan Calhanoglu delivering set-pieces and Nicolo Barella driving forward, goalscoring opportunities will arrive for the hosts. Sassuolo, despite beating Lazio, still conceded plenty of chances, and their defensive unit remains fragile.

As BettingTips4You.com expert Luca Pratesi explained:

“Inter’s back line remains shaky in the league, while Sassuolo’s defence is not exactly watertight either. Both sides have enough quality in attack to find the net.”

The game feels primed for an exchange of blows. Inter should eventually have too much, but Sassuolo’s ability to pounce on lapses cannot be ignored. A 2-1 win for Inter Milan looks the most realistic scoreline, balancing their attacking firepower with the likelihood of Sassuolo breaking through.

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