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The fourth week of the NFL season begins in the desert, and Thursday night brings with it one of the most intriguing contests of the round. Arizona host Seattle at State Farm Stadium in what is already shaping up to be a pivotal divisional clash. Both sides enter with 2–1 records, but the path to this stage has been far from identical. Read on to find a detailed preview and the best bet recommendation for this clash, and don’t forget to take advantage of the selected betting offers listed below to maximise your betting value.
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NFL betting tips: Seattle Seahawks at Arizona Cardinals predictions
Can the Cardinals’ Defence Contain Seattle’s Surging Attack?
- Seattle have generated 32 quarterback pressures despite blitzing just eight times this season
- Jaxon Smith-Njigba commands a 37.7% target share, the second highest in the NFL
- Trey McBride leads all tight ends in the league with a 27% target share
Our Best Bet
Kyler Murray Over 275 Passing Yards & Kyler Murray Over 2 Passing Touchdowns | |
11/1 - odds when tipped | |
Reasoning With James Conner out, Arizona will be forced to throw more often. Kyler Murray’s workload should soar against a Seattle defence that can be moved through the air. Backing him to clear 275 passing yards and at least two touchdowns at 11/1 offers excellent value in this divisional battle. | |
Seattle arrive brimming with momentum, having dismantled New Orleans 44–13 last time out. Their attack has been flowing smoothly, with quarterback Sam Darnold looking composed in his new surroundings and distributing the ball effectively. The defensive unit has also caught the eye, allowing minimal scoring opportunities and displaying a relentless ability to hurry opposing passers without leaning heavily on blitzes.
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Arizona, in contrast, come into this match licking their wounds. A narrow 16–15 defeat to San Francisco in Week Three will still sting, particularly as they had chances to close out the game. Their early wins against New Orleans and Carolina came without fully convincing, and the loss of running back James Conner to a season-ending injury further complicates matters. While Kyler Murray continues to guide the offence, his connection with Marvin Harrison has not yet reached the level Cardinals fans would have hoped for, with costly drops disrupting their rhythm.
With both sides eyeing an early foothold in the tightly packed NFC West – where all four teams currently hold winning records – the scene is set for a compelling battle under the primetime lights. The clash promises not only to test individual match-ups but also to reveal which team can truly assert itself as a contender within the division.
Best Bet for Thursday Night
Here at BettingTips4You we focus on quality over quantity, and as always, we are presenting just one carefully considered prediction for this match. This approach makes it clear and accountable, allowing readers to track performance without being overwhelmed by multiple suggestions. For Thursday’s divisional showdown, our standout selection is:
Kyler Murray Over 275 Passing Yards & Kyler Murray Over 2 Passing Touchdowns at 11/1
Why This Bet Holds Value
The rationale behind backing Murray to hit both marks stems from how this particular contest is shaping up. With James Conner sidelined for the year, Arizona’s ground game is left considerably weakened, forcing the Cardinals to lean even more heavily on their quarterback to shoulder the offensive load. Without a proven rushing option to consistently move the chains, Murray is likely to attempt a far higher volume of passes.
The Seahawks’ defensive strength lies in limiting points on the scoreboard, but their soft spot has been against tight ends and in dealing with high passing volume. Trey McBride has been one of the Cardinals’ most reliable weapons so far, leading the team across nearly every receiving metric and commanding a striking 27% target share. Expect McBride to be heavily involved as Murray looks to find safe outlets under pressure.
Arizona’s receiving corps have also seen chances, with Marvin Harrison being targeted regularly, even if execution has not always matched intent. Given the short week and injuries in the Cardinals’ secondary, there is every reason to believe that Murray will be asked to throw more aggressively to keep pace with a Seattle side that has looked sharp through the air. The Cardinals’ coaching staff know that to compete they must challenge downfield, and Murray, despite a modest 56.3 rating so far, has the tools to exploit volume.
Seattle may well prevail, but the structure of the game points towards Murray exceeding 275 passing yards and delivering multiple touchdown throws. At 11/1, the value lies in his workload becoming the deciding factor in keeping Arizona competitive.
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