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The NFL returns to the capital on Sunday, 19th October, for its third and final London fixture of the 2025 season. Following two well-attended contests at the Tottenham Hotspur Stadium, the focus shifts to Wembley Stadium, where the Jacksonville Jaguars meet the Los Angeles Rams in what promises to be a fascinating clash between two sides boasting identical 4-2 records. Read on for the best bet for this event and the analysis in addition to the best betting offers to take full advantage of.

NFL betting tips: Los Angeles Rams vs Jacksonville Jaguars predictions
Could Wembley Witness Another High-Scoring London Classic?
- Both teams enter Wembley with identical 4-2 records, highlighting how evenly matched this contest could be.
- Travis Etienne’s 5.3 yards per carry underline Jacksonville’s commitment to an efficient ground game.
- Matthew Stafford’s tally of 12 touchdowns against only two interceptions showcases his current precision under pressure.
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Kyren Williams’ red-zone role and goal-line trust make two touchdowns realistic. With Puka Nacua sidelined, Los Angeles should lean heavier on run concepts and designed checkdowns that set up short fields. Stafford’s efficiency widens rushing lanes, and Jacksonville’s interior has wobbled. At 5/1, the multi-TD outcome offers compelling, calculated value.
The 2.30pm kick-off, televised live on Sky Sports NFL and Channel 5, brings together a team deeply familiar with London’s atmosphere against a Californian outfit eager to make their mark in front of a British audience.
For Jacksonville, this matchup represents more than a showcase event. Having hosted regular games in the UK over the years, the Jaguars have effectively made London their second home. Their familiarity with the unique demands of transatlantic travel and local conditions could play a significant part in determining the outcome. They arrive following a mixed fortnight—first celebrating an impressive win over the Chiefs, then suffering a setback against the Seahawks. Under new leadership this season, the Jaguars’ offence has looked reinvigorated, with a strong ground game led by Travis Etienne, who has averaged an impressive 5.3 yards per carry so far.

Across the field, the Rams have also opened their campaign in encouraging fashion. Their most recent victory came against an injury-depleted Ravens team, which, while useful for momentum, didn’t present much of a defensive test. Quarterback Matthew Stafford continues to operate efficiently, having already thrown 12 touchdowns to just two interceptions this term. However, Los Angeles will need to adapt without key receiver Puka Nacua, whose absence through injury removes a vital deep threat from their offensive arsenal.
With both teams well-matched and the total points line sitting around 44.5, this encounter looks set to deliver a balanced mix of physicality and flair. The Jaguars’ experience on British soil and the Rams’ high-functioning passing attack offer intriguing contrasts in approach, and the neutral venue could tilt the balance either way.

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Best Bet for the Day: Kyren Williams To Score 2 Or More Touchdowns at 5/1
Here at BettingTips4You, we believe in precision over quantity. Rather than overwhelming readers with multiple selections, we provide just one carefully chosen prediction per event. This ensures total clarity and accountability—our readers know exactly what we’re backing and can easily assess the value of our insights over time.
Kyren Williams to score two or more touchdowns at 5/1 stands out as the best bet for Sunday’s action at Wembley. Williams has become increasingly influential in the Rams’ red-zone strategy, often trusted to finish off promising drives. With Nacua sidelined, the Rams are expected to rely more heavily on their running game, giving Williams additional opportunities near the goal line. His ability to break tackles and his instinct for finding gaps in the opposition’s defence make him an obvious threat, particularly against a Jaguars unit that has occasionally struggled to contain power runs between the tackles.
Furthermore, Matthew Stafford’s efficient passing game helps to open running lanes for Williams, as defensive units are forced to respect the threat through the air. With Jacksonville’s defence likely focused on containing Stafford’s aerial options, Williams could benefit from lighter fronts and more red-zone carries. At 5/1, the price offers considerable value for a player who could well feature prominently in a high-scoring affair.
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