NFL betting tips: Divisional predictions, preview and best bets for NFC West

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As the curtain prepares to rise on the 2025 NFL season, the NFC West stands out as one of the league’s most open divisions. With all four teams having genuine aspirations, this section of the competition promises drama, unpredictability, and shifting momentum week to week. Unlike other divisions, where a clear hierarchy is already forming, the NFC West appears delicately poised, with no outright frontrunner. Read on to find a detailed preview and the best bet recommendation for this season, and don’t forget to take advantage of the selected betting offers listed below to maximise your betting value.

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NFL betting tips: Divisional predictions for NFC West

Can the Balance of Power Shift in the NFC West This Season?
  • Arizona improved from 4-13 to 8-9 last season, despite a difficult run of fixtures
  • Marvin Harrison Jr. has bulked up ahead of 2025, aiming for better chemistry with Kyler Murray
  • Josh Sweat and Calais Campbell join the Cardinals’ defence, adding edge pressure and experience

Our Best Bet

Arizona Cardinals to Win the Division
4/1 - odds when tipped
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Reasoning
The Cardinals improved significantly last season and now face a much more manageable fixture list. With Kyler Murray better supported by Marvin Harrison Jr. and James Conner, and a reinforced defence, Arizona are in position to leapfrog more hyped rivals. At 4/1, the value here is too good to ignore.

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While the San Francisco 49ers and Los Angeles Rams enter with plenty of expectations, there are reasons for caution. The 49ers, for all their talent, face question marks after a turbulent 2024 campaign. Injuries were a major issue last season, and although their key running back is expected to be back in action, the lack of consistency remains a concern. Meanwhile, the Rams are hoping for another strong year but their success may hinge on the fitness of their experienced quarterback. If he remains unavailable for any stretch of the season, their chances of defending the division title could suffer significantly.

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Seattle are also attempting a reset, having changed their starting quarterback and brought in Cooper Kupp to reinvigorate their offensive unit. However, their offensive line remains an issue, and it’s difficult to predict whether this revamped attack can deliver consistent results across 17 games. They will need to stay healthy and find cohesion quickly if they want to stay competitive in a division that punishes any lapses.

Then there are the Arizona Cardinals — a side quietly improving and perhaps going under the radar. They might not have dominated headlines during the offseason, but their strategic recruitment and internal growth suggest a team ready to take a substantial step forward. After going 8-9 last year, there’s a growing sense that they are beginning to put the right pieces together at exactly the right time. With a more favourable schedule in 2025, the Cardinals could be poised to surprise more established rivals.


Best Bet: Arizona Cardinals to Win the Division

At BettingTips4You, we prioritise quality over quantity. That’s why we present just one carefully selected tip for each event — no noise, no confusion, just a single, clear recommendation. For the upcoming NFC West season, our Best Bet is backing the Arizona Cardinals to win the division at 4/1.

There’s a compelling case to be made for Arizona this year. After enduring a brutal schedule in 2024, they still managed to string together eight wins, showing real grit and promise under pressure. Head coach Jonathan Gannon appears to have established a solid platform, and the squad around quarterback Kyler Murray is shaping up nicely. Marvin Harrison Jr. is expected to be far more integrated this season, especially after adding muscle and sharpening his route-running — developments which should help sync him better with Murray. With James Conner offering stability from the backfield and Zay Jones providing another reliable target, Arizona’s offence seems ready to operate at a higher gear.

Defensively, improvements are evident. The addition of Josh Sweat bolsters the pass rush, while the leadership brought in by Calais Campbell shouldn’t be underestimated. This isn’t a defence that needs to be elite — just one that can hold its ground while the offence delivers points. With a much softer fixture list ahead, Arizona look primed to outperform expectations. Considering how tight the division is, 4/1 represents genuine value, especially with rival teams carrying major uncertainties of their own. This is a calculated risk that could pay off handsomely.

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Steve Harrington is a sportswriter whose heart beats for football. With a passion that began in the grassroots, he's witnessed the magic of the game from local pitches to grand stadiums. Over the past 7 years, Steve has lent his expertise to several online publications, chronicling the ever-evolving world of football. Beyond his professional pursuits, he holds a special affection for Burnley Football Club, cherishing every triumph and tribulation. Steve believes in the power of storytelling and its ability to bring the beautiful game closer to its ardent fans.